ABSTRACT

Aim and objective: The aim of the present study was to develop the nanoparticles consisting etoricoxib with ethanolic extract of ginger (Zingiber officinale, Zingiberaceae) root and tulsi (Ocimum sanctum L, Lamiaceae) leaves prepared nanoparticles using Chitosan as polymers treatment of diabetes complications. Material and method: Nanoparticles were prepared by the antisolvent method by using a different concentration of polymer (Chitosan) and extract while concentration of etoricoxib was remain constant in all the formulations. The prepared nanoparticle was evaluated for different parameters. Result & discussion: The formulation of nanoparticles was evaluated for various parameters such as viscosity, washability, consistency, pH, spreadability and in-virro drug release study. The constancy of the formulations size of pores was found ranging from 924 nm was observed. The pH of the nanoparticles was found to be 6.1±0.009 (F2) to 6.1±0.098 (F7) whereas the viscosity was found in the range of 0.901±0.010 (F7) to 1.200±0.055 micm3 (F9). The Spreadability was found in the range of 61.9±0.025 % (F5) to 71.01±0.016 % (F4). The drug content of etoricoxib in the formulations was found in the range of 63.9±0.11 (F8) to 77.5±0.06 (F9). GE 58.9±0.01 (F7) to 62.9±0.05 (F1) and BE 35.9±0.01 (F3) to 64.9±0.05 (F9). The drug release was taken up to 24 h and found to be 99 % for all the formulations. Conclusion: The results showed that the nanoparticles were prepared successfully. Keywords: Nanoparticles, Chitosan Polymers, Ocimum Tenuiflorum, Zingiber Officinale
Publication date: 01/07/21

https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5545.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.7.5545