ABSTRACT

Current treatment methods of cancer include surgical intervention and the usage of chemosynthetic drugs or natural products. However, the synthetic drugs show broadspectrum cytotoxicity and a higher dose for cellular inhibition. Therefore, using an amino acid like Lysine for the cancer treatment raises a new hope, as this therapeutic molecule bears no cytotoxicity towards the normal cells and works by altering the cellular metabolism from the very first stage of cancer development. Lysine was found to be significant when applied as a single moiety or in a derived form and also in a combinational form with the other drugs. This review elaborates on the current state of development, recent advancement of this amino acids highlighting the application of Lysine against several cancer cells. Overall, the effectiveness of Lysine and the molecules that it targets for the inhibition of cancer proliferation emerge a new area in the anticancer research, which proves Lysine as a potential aspirant drug in cancer therapy. Keywords: L-lysine; cancer; cytotoxicity; apoptosis; therapy
Publication date: 01/12/2020

https://ijbpas.com/pdf/2020/December/MS_IJBPAS_2020_5181.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.12.5181