ABSTRACT

BK virus (BKV) is a polyomavirus that associated nephritis (BKVAN) and a significant risk factor for renal transplant dysfunction and allograft survival. The pathogenesis of BKVAN needs to be further investigated and the virus functions as still unclear; nevertheless there are a variety of hypotheses that indicate, host factors play important roles. Higher prevalence of BK virus infection in recent years has been correlated with acute rejection rates and the use of potent immunosuppressive agents. Although over immunosuppression remains the primary risk factor for BK infection after transplantation, male gender, older recipient age and ureteral stent placement implicated as risk factors. The diagnosis of BKV is laboratory based method for its effects in urine, blood, and renal tissue. Some laboratory assay has provided new insights into the immune response to BK and may help guide therapy in the future. In the past, approximately 30 to 60% of patients with BK virus nephritis developed graft failure but early detection and routine screening has been shown to be effective in preventing allograft loss. In the study, we screened 1240 patients and out of these 106 (8.54%) found positive for BKV. The rate of viruria and viremia were 69 (65%) and 37 (34.9%) out of total BKV positive. Their mean of serum creatinine level were 1.56±0.2 mg/dl and 2.39 ± 0.3 mg/dl in viruria and viremia, respectively. Keywords: BK virus (BKV), Immunosuppression, Nephritis, Kidney Transplantation, Allograft Survival

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https://doi.org/10.31032/IJBPAS/2019/8.2.4641