Introduction
Metabolic syndrome is a multi-faceted global health challenge characterized by a cluster of
interconnected risk factors that increase the likelihood of cardiovascular diseases, diabetes, and
related disorders. This systematic review critically evaluates the existing literature on the
therapeutic effects and possible mechanism of action of Unani single drugs, Darchini
(Cinnamomum Zeylanicum), Hulba (Trigonella foenum), and Jaiphal (Myristica fragrans) in
managing various components of metabolic syndrome, such as obesity, insulin resistance,
dyslipidemia, and hypertension.
Results:
The findings indicate that Darchini, Hulba, and Jaiphal, either individually or in combination,
exhibit promising anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic
properties. These herbs were found to improve insulin sensitivity, lipid metabolism, reduce
adiposity, and help regulate blood pressure. The review also highlights the potential
mechanisms of action, which include the modulation of insulin signalling pathways, adipokine
secretion, and lipid metabolism.Conclusion:
This review enhances the understanding of Unani medicine as a potential therapeutic approach
for metabolic syndrome. It underscores the promising effects of Darchini, Hulba, and Jaiphal
and provides insights for future research and clinical applications, including safety
considerations and potential adverse effects.
Keywords: Cinnamon; Fenugreek; Nutmeg; Metabolic Syndrome; Insulin resistance;
Syndrome
Publication date: 01/03/2026
https://ijbpas.com/pdf/2026/March/MS_IJBPAS_2026_10020.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.3.10020
