ABSTRACT

This article focuses on the role of hyperlipidemia in Diabetic Neuropathic Pain. It gives idea about the complex relationship between Hyperlipidemia and Diabetic neuropathic pain, exploring the potential mechanism and clinical implications. Diabetic neuropathic pain is an enfeebling complication of diabetes. According to the International Diabetic Federation, about 425 million people worldwide are affected by diabetes. More than 90% of the Diabetic subjects are affected by Distal Symmetrical Polyneuropathy. Neuropathic pain affects the somatosensory nervous system through lesions or disease resulting in the peripheral or central system. Diabetic neuropathic pain generally occurs in type 2 diabetic patients. It also gives idea about types of neuropathic pain such as Nociceptive (stimulation of peripheral nociceptors in the skin, joint, and muscle) and Neuropathic (pain generated by damage to the nervous system). In this review classification according to site of inflammation with types of Neuropathic pain is also discussed. While Hyperlipidemia (a disorder of high lipid levels in the blood) is a rooted risk factor for Diabetes, its specific contribution to Diabetic Neuropathic Pain remains unclear. Hyperlipidemia imparts Neuropathic pain through oxidative stress, endothelial dysfunction, inflammaThis article focuses on the role of hyperlipidemia in Diabetic Neuropathic Pain. It gives idea about the complex relationship between Hyperlipidemia and Diabetic neuropathic pain, exploring the potential mechanism and clinical implications. Diabetic neuropathic pain is an enfeebling complication of diabetes. According to the International Diabetic Federation, about 425 million people worldwide are affected by diabetes. More than 90% of the Diabetic subjects are affected by Distal Symmetrical Polyneuropathy. Neuropathic pain affects the somatosensory nervous system through lesions or disease resulting in the peripheral or central system. Diabetic neuropathic pain generally occurs in type 2 diabetic patients. It also gives idea about types of neuropathic pain such as Nociceptive (stimulation of peripheral nociceptors in the skin, joint, and muscle) and Neuropathic (pain generated by damage to the nervous system). In this review classification according to site of inflammation with types of Neuropathic pain is also discussed. While Hyperlipidemia (a disorder of high lipid levels in the blood) is a rooted risk factor for Diabetes, its specific contribution to Diabetic Neuropathic Pain remains unclear. Hyperlipidemia imparts Neuropathic pain through oxidative stress, endothelial dysfunction, inflammation andaltered lipid metabolism. We have described methods for inducing hyperlipidemia in animals and in humans. Triton is the drug used for inducing hyperlipidemia in animals. Many drugs such as poloxamer, cholicacid, lithium chloride may be used to induce hyperlipidemia in animals. The review also gives idea about experimental procedures which is needed for inducing hyperlipidemia, the types of subject required, and serum analysis. This review emphasizes that Hyperlipidemia can be managed by lifestyle modification; pharmaceutical mediation may help in reducing Neuropathic pain. Keywords: Hyperlipidemia, Neuropathic Pain, Diabetic Neuropathic Pain
Publication date: 01/03/2026

https://ijbpas.com/pdf/2026/March/MS_IJBPAS_2026_10001.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.3.10001