ABSTRACT

The main aim of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a sufficient period of time to elicit the response. To overcome the drawbacks of conventional ophthalmic dosage form, many progresses have been done to improve the pre-corneal drug absorption and minimize pre-corneal drug loss. Preparation of ocursert helps to retain the volume and increase contact time. Topical administration of drugs is the most favoured route for management of ocular inflammation as it provides higher ocular drug concentration keeping away the systemic side effects associated with other method of administration. Ciprofloxacin is a fluoroquinolone antibiotic used to treat different types of bacterial infections like conjuctivitis. The goal of the present study is to formulate and evaluate ciprofloxacin niosomal ocuserts for ophthalmic delivery. In this study Ciprofloxacin niosomes were prepared by using ether injection method using span 60 as surfactant. High entrapment efficiency and invitro drug release can be obtained by the preparation of niosomes. Niosomes are optimized by 3² Full factorial design using design expert software version 13 stat Ease. From the release kinetics it is evident that the drug ciprofloxacin is released in a sustained manner over a period of time and shows zero order model. 9 formulation were prepared and incorporate the best niosomes into ocusert. Preparation of ocusert by solvent casting method using hydroxy propyl methyl cellulose as polymer. For the prepared ocusert drug content was found to be 96% and invitro drug release at the end of 7 hours was found to be 77.2%. Solubility can be increased with preparation of this biocompatible ocusert. Controlled and prolonged drug delivery can be achieved by preparation of ocusert. Achieve increased ocular contact time and reduce precorneal losses. To increase ocularbioavailability of the drug pH of the ocular formulation should be similar to pH of tear fluid, in this preparation it was found to be 6.9 and is satisfactory. Keywords; ciprofloxacin, span 60, entrapment efficiency, hydroxy propyl Methyl cellulose, Ether injection, solvent casting
Publication date: 01/03/2026

https://ijbpas.com/pdf/2026/March/MS_IJBPAS_2026_9997.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.3.9997