ABSTRACT

Amaranthus spinosus L., commonly known as spiny amaranth, was collected, authenticated and dried by the Central National Herbarium of the Botanical Survey of India. The dried whole plant was subjected to extraction using a hydro-alcoholic solvent (70% ethanol and 30% distilled water) through the maceration method. Phytochemical screening of the extract disclosed the existence a number of bioactive components, including alkaloids, carbohydrates, amino acids, flavonoids, glycosides, mucilage, tannins, proteins and terpenoids, all of which are known for their multiple pharmacological properties. In vitro pharmacological investigations were conducted to evaluate the plant’s potential therapeutic effects, particularly its anti- ulcer and anti- arthritic activities of the hydro-alcoholic extract when compared to standard drugs used for these conditions. The extract exhibited protective effects on the gastric mucosa, which may contribute to its anti- ulcer activity and anti- inflammatory effects, which may assist alleviate the symptoms of arthritis such as pain and swelling. The observed pharmacological effects are likely due to the synergistic action of multiple phytochemicals existing in the plant, although further studies are required to isolate and identify the specific compounds responsible for these activities. These works suggests that Amaranthus spinosus L., may hold promise as a natural therapeutic agent for the treatment of gastric ulcers and inflammatory arthritis. Keywords: Anti- ulcer, Anti- arthritic, Amaranthus spinosus L., in- vitro, hydro-alcoholic
Publication date: 01/03/2026

https://ijbpas.com/pdf/2026/March/MS_IJBPAS_2026_9986.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.3.9986