ABSTRACT

Ethosomes, advanced lipid-based vesicular carriers, have emerged as a promising transdermal drug delivery system. Their unique structure, consisting of phospholipids, ethanol, and water, enhances the penetration of active compounds through the stratum corneum, making them highly effective for topical applications. Ethosomal formulations have found extensive use in cosmeceuticals, pharmaceuticals, and veterinary science. Several studies demonstrate their ability to improve the bioavailability of both hydrophilic and lipophilic drugs, with applications ranging from anti-aging skincare to the treatment of hyperpigmentation, acne, and skin infections. Ethosomal systems are also being explored for transdermal delivery of more complex molecules, including proteins and peptides. Despite the various benefits, including high patient compliance and simple formulation techniques, ethosomes face challenges such as low yield and high production costs. Continuous advancements and commercialization efforts are contributing to their growing relevance in therapeutic and cosmetic markets. Keywords: Ethosomes, cosmeceuticals, transdermal drug delivery, phospholipid vesicles, skin penetration
Publication date: 01/02/2026

https://ijbpas.com/pdf/2026/February/MS_IJBPAS_2026_9876.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.2.9876