ABSTRACT

This review mainly focuses on the novel approaches for selection of the drug delivery system for colon diseases which is helpful in increasing the therapeutic effect of the drug at the desired site. Colon-targeted drug administration not only reduces side effects but also prevents premature drug release in the stomach or small intestine before reaching the colon. There are several approaches for the delivery of the drug in the colon. The novel strategies employed in the formulation of colon targeted drug delivery system (CTDDS) are meant to postpone the drug's release until the colon is reached. This article focuses on the parameters that affect colonic bioavailability, the different approaches used for colon-specific drug delivery, as well as the drawbacks of CTDDS. Keywords: Colon targeted drug delivery, Smart novel approaches, Challenges, pH sensitive polymers
Publication date: 01/02/2026

https://ijbpas.com/pdf/2026/February/MS_IJBPAS_2026_9863.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.2.9863