Metabolic disorders, a diverse group of conditions caused by disruptions in the body’s
metabolic processes, can significantly impact health and quality of life. These disorders may
be inherited or acquired, and they often result from enzyme deficiencies or defects in
biochemical pathways. Early detection, typically through newborn screening, is critical for
managing many inherited metabolic disorders. Metabolic disorders include an assemblage of
diseases whose pathogenesis is varied to say the least. Metabolism comprises all of the
chemical reactions that take place in a living system, be it a cell, a tissue, an organ, or an
organism. Metabolic reactions are almost all enzyme-catalysed and include transformations of
energy and nutrients, syntheses and degradations, and excretions of waste products. Chemical
changes concerned with the production, storage, and utilization of metabolic energy for
biosynthesis are known as intermediary metabolism. Typically, intermediary metabolism
includes all aspects of metabolism (including digestion) except those involved in the transfer
of genetic information-replication, transcription, and translation. Metabolic disorders are
conditions that affect the body's normal metabolic processes, leading to issues with energy
production, storage, or utilization. Examples include diabetes, phenylketonuria (PKU), and
lysosomal storage disorders. Treatment often involves lifestyle changes, medications, or
specialized diets, depending on the specific disorder
Keywords: Intermediate metabolism, glycogen storage disease, amino acid, nucleotides,
digestive fluid, Pompe’s disease
Publication date: 01/02/2026
https://ijbpas.com/pdf/2026/February/MS_IJBPAS_2026_9844.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.2.9844
