ABSTRACT

Background: Rasa Aushadhi’s are known to play an important role in therapeutics due to their nanoparticle characteristics. A systematic study of the manufacturing processes for these formulations is essential to ensure their quality, safety, and efficacy, thereby preserving the deep trust patients have in Ayurveda. Aim & objectives: The present study aimed to prepare SPR as per the methods mentioned in the classical text and to characterize it physio-chemically using available analytical techniques. Materials & Methods: All the raw drugs were subjected to shodhana as per classical SOP and the final product was prepared by classical kupipakwa method by giving bhavana with Tulasi swarasa for three days. The qualitative and quantitative estimations were done for raw drugs, intermediate and final product. The characterization was done through XRD, SEM, FTIR, and ICP-AES Analysis. Results and Discussion: During the Sameera Pannaga Rasa preparation it was found that the time duration of Madhyama agni was longest i.e. 14 hrs which might be due the chemical reaction between organic and inorganic materials and obtaining the stable form. The maximum temperatureobtained after corking was 6170C. Final product was obtained in shiny black colour. XRD Analysis reveals the final composition corresponding to HgS and As2O3 only. Particle size was found to be ranged between 1-50 micrometre owing to its good absorption. FTIR Analysis revealed the presence of various functional groups such as alcohol, alkenes, aliphatic and secondary amines which might correspond to the functionality of final product. ICP-MS Analysis confirms the predominance of arsenic in the final product. Conclusion- The results of this study certainly can be utilized as baseline data for quality assurance of this herbo-mineral formulation. The preliminary profiles of Sameerapannaga rasa evaluated in this attempt could be used to lay down a new set of pharmacopeial standards for further research studies. Keywords: Sameerapannaga Rasa, rasa aushadhi, Kupipakwa, Pharmaceutico-analytical, Characterization
Publication date: 01/02/2026

https://ijbpas.com/pdf/2026/February/MS_IJBPAS_2026_9839.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.2.9839