ABSTRACT

Diabetes mellitus is a chronic metabolic disorder, and the rising incidence of diabetes worldwide is a significant concern in both developed and developing countries. The limitations in efficacy and safety of currently available oral antidiabetic medications, along with the global epidemic of diabetes, have contributed to the growing interest in alternative therapies for managing the disease more safely and effectively. Herbal medicines are increasingly recognized as a viable alternative for controlling blood sugar levels. The objective of the study was to evaluate the antidiabetic activity of three medicinal plants (A. obesum, C. glandulosum, and S. sativa) using streptozotocin-induced non-insulin-dependent diabetes mellitus (NIDDM) in Wistar rats. The study investigated the effects of plant extracts on blood glucose, insulin levels, and various biochemical markers. In addition, the in vitro enzyme inhibitory activity of the plant extracts was studied. The administration of polyherbal extract orally at doses of 200 and 400 mg/kg significantly decreased the blood glucose levels compared to the control diabetic rats. The results indicate significant antidiabetic activity in the plant extracts, confirming their potential use as natural treatments for diabetes. Keywords: Antidiabetic activity, A. obesum, C. glandulosum, S. sativa, streptozotocin, NIDDM, enzyme inhibitory activity
Publication date: 01/02/2026

https://ijbpas.com/pdf/2026/February/MS_IJBPAS_2026_9741.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.2.9741