ABSTRACT

Solubility is critical for attaining the intended drug concentration in systemic circulation, especially for lipophilic drugs with poor water solubility like Zaltoprofen, a class II BCS medication with very low bioavailability. This study aimed to create a solid dispersion (SD) of Zaltoprofen to improve its dissolution rate and formulate a fast-dissolving tablet using hydrophilic carriers. Solid dispersions were prepared via physical mixture, kneading, solvent evaporation, and fusion methods with carriers such as urea, mannitol, ?-cyclodextrin, PEG 6000, PVP K30, and Poloxamer 188 in various ratios (1:2, 1:4, 1:6). Tablets were formulated using direct compression method. Pure Zaltoprofen showed a water solubility of 0.013±0.04 mg/ml. Solid dispersion solubility, drug content, and in vitro dissolution tests showed positive results, with the best solid dispersion used for tablet formulation. Post-compressional studies indicated good hardness, friability, and rapid disintegration times. Formulation F2 showed the highest stability under accelerated conditions and improved in vitro release compared to the pure drug. The findings conclude that Zaltoprofen's solubility and dissolution rate can be significantly enhanced using solid dispersion techniques with appropriate hydrophilic carriers. Keywords: Zaltoprofen; enhanced solubility; solid dispersion; fast dissolving tablets
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9782.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.1.9782