ABSTRACT

An oral hypoglycemic medication called Metformin (biguanide) is frequently prescribed to treat type 2 diabetes mellitus. It is a medication from BCS class III with high solubility and limited permeability. In this study, we looked at how ABC (Apple, Beetroot, and Carrot) juice affected the oral bioavailability of metformin (50–60%) as well as serum levels of HDL, cholesterol, and triglycerides. There were three groups of three rats each. Group II received normal saline solution for one week along with oral Metformin (70 mg/kg) on the seventh day of the research, while Group I simply received normal saline solution. On the seventh day of the research, Group III received oral Metformin (70 mg/kg) along with ABC juice for a week. It was discovered that the highest reduction in glucose levels in both Groups (II and III) occurred during the 6th hour in diabetic rats. It was discovered to be 23.18% in rats given Metformin and around 20.3% in rats given ABC juice as a pretreatment. The higher HDL values in group III compared to group II suggest that ABC juice can raise levels of the good cholesterol. However, when compared to rats given with Metformin alone during the research period, a significant benefit could not be seen in rats pretreated with ABC juice. Keywords: Metformin, Diabetes mellitus, ABC Juice, Triglycerides, Bioavailability
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9773.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.1.9773