ABSTRACT

Background: Diabetes mellitus is a multifactorial disorder characterized by a chronic elevation in blood sugar levels. Currently, antidiabetic drugs are available in order to counteract the associated pathologies. Their connected effects are necessitated to the investigation for a good and safe drug aimed to diminish blood sugar levels with fewer side effects. Method: The present study was undertaken to review the role of natural products using in silico interaction studies. Molecular docking studies were carried out with3 target proteins to evaluate its antidiabetic potential Luteolin is a compound present in Abutilon indicum was found as a potential anti- diabetic agent. Result: The study showed the highest interactions with 3W37 (-8.8 kcal/mol). Molecular docking analysis resulted in favourable binding energy of interaction ranging low as - 5.1 to - 8.8 kcal/mol for luteolin, in silico pharmacokinetics and toxicity profile of luteolin were studied using SwissADMET, PKCSM online software’s. It was predicted that luteolin as non-carcinogenic and non-mutagenic. The drug-likeliness was calculated using PYRx respecting Lipinski’s rule of 5. The compound was found to adjust to Lipinksi rules. Conclusion The study suggested that luteolin can be a possible anti-diabetic agent. As it showed prominentresults Keywords: Diabetes mellitus, molecular Docking, luteolin, Insilco analysis, PYRx, SwissADMET, PKCSM
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9771.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.1.9771