ABSTRACT

Introduction: Osteoarthritis is a low grade inflammatory and degenerative joint disease involving varies of molecular interactions between the tissues that form the joint. Janu Sandhigata Vata can be understood in parlance with knee osteoarthritis (OA) which has a great impact on the quality of life. This study is aimed to evaluate the effect of kinva upanaha on inflammatory biomarkers in janu sandhigata vata. Objectives: To evaluate the efficacy of Kinva Upanaha on inflammatory biomarkers (TNF- ? IL- 6) in Knee osteoarthritis w.s.r to Janu Sandhigata Vata. Methods: Basic Phytochemical, Microbial testAmrutarishta Kinva were done and kinva upanaha was done for 20 diagnosed patients of janu sandhigata vata for 7 days for 5 hours duration. Janu Sandhi shola by Visual analogue scale, Knee Range of Movements were assessed on 7th day and 14th day from the day of enrollment, whereas inflammatory biomarkers (TNF- ? IL- 6) were assessed on the 1st and 7th day from the day of enrollment. The paired “t” test and the Wilcoxon match-paired test were applied to evaluate the results. Results: Kinva Upanaha therapy showed reduction in serum levels of inflammatory biomarkers (TNF-? and IL- 6) and improvement in Knee pain and Knee Range of movements too. Conclusion: Kinva upanaha yielded positive subjectiveand inflammatory biomarker outcomes in knee osteoarthritis. Kinva is residueand is discarded by most of the pharmacies but this can become an economical and potent upanaha drug in knee osteoarthritis. Keywords: Inflammatory biomarkers, Knee osteoarthritis, Kinva Upanaha Sweda
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9765.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.1.9765