ABSTRACT

This study focuses on the optimization and evaluation of fexofenadine hydrochloride sublingual films aimed at treating allergic rhinitis. Films were prepared using the solvent casting method and optimized with Box-Behnken design, a response surface methodology, to refine the formulation parameters. Variables such as polymer concentration, plasticizer content, and disintegrant concentration were systematically varied to determine their effects on film properties. The optimized films demonstrated favourable characteristics including appropriate thickness, disintegration time, folding endurance, and in-vitro drug release profile. These results suggest that the solvent-cast sublingual films of fexofenadine hydrochloride are effective for sublingual delivery, providing a promising solution for allergic rhinitis management with potential benefits in patient compliance and therapeutic onset. Future research will involve in vivo testing and clinical trials to validate the efficacy and safety of these films. Keywords: Optimization, Bioavailability, Sublingual Film, Design of Experiments, Fexofenadine Hydrochloride
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9757.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2026/15.1.9757