ABSTRACT

The last 20 years have seen a significant increase in interest in substituted thiazolidinones due to their diverse biological activities and multitude of medicinal applications. To sum up, we want to create novel, extremely effective substituted thiadiazole molecules with minimal side effects. The current study produces thiazolidene-2, 4-dione by refluxing thiourea and chloroacetic acid for 40 hours. The scaffold for thiadiazole is produced by this technique. 5-(4- ethoxybenzylidene)-1,3-thiazolidine-2,4-dione was produced by refluxing thiazolidine-2,4- dione with 4-ethoxybenzaldehyde and sodium acetate in glacial acetic acid medium for 12 hours. The final scaffold was created by combining 5-(4-ethoxybenzylidene)-1, 3-thiazolidine- 2, 4-dione with substituted 2-aminopyridine utilizing the Mannich base reaction. These compounds that were produced were examined using LC-MS, HNMR, and IR spectroscopy. The disc-diffusion technique was utilized to evaluate anti-bacterial activity these synthetic compounds. Anti-inflammatory activity of synthesized compounds screened by carrageenan induced paw oedema model & Eddy’s hot plate method where used for analgesic activity. Keyword: Anti-bacterial activity, Thizolodine, 2-amino pyridine, Disc-diffusion method
Publication date: 01/01/2026

https://ijbpas.com/pdf/2026/January/MS_IJBPAS_2026_9709.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2026/15.1.9709