ABSTRACT

The effectiveness of any formulation depends on the delivery of the effective level of the therapeutically active compound. The term “Phyto” means plant and “some” means cell It is also mentioned as herbosomes this is a new patented technology, where standardized plant extracts or water soluble phytoconstituents are complexed with phospholipids to produce lipid compatible molecular complexes, there by greatly increasing absorption and bioavailability. Phytosomes are complexes of phospholipids and naturally active phytochemicals that have been widely used in medicine since ancient times. This system allows a phytoconstituent to enter the bloodstream through the inner membrane of the intestine. The improved absorption and pharmacological properties of phytosomes can be used to treat various diseases. Phytosomes are superior to conventional drug delivery systems due to their pharmacokinetic and pharmacodynamic properties. Most of the bioactive compounds in phytomedicines are soluble in water. They include flavonoids, terpenoids, and glycosides in which flavonoids perform broad therapeutic activities. The phytoconstituents, especially polyphenolic and flavonoids, have various pharmacological activities such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, anti-obesity as well as cardioprotective. The bioavailability of polyphenolic compounds can be improved by integrating them into the phospholipid-based self-assembled delivery systems, which are referred to as phytosomes or herbosomes. Phytosomes are vesicles in which the phospholipids bond with the hydrogen in the polyphenolic components to deliver the drugs to the targeted site without their metabolism. Keywords: Phytosomes, Phyto-phospholipid complex, Phospholipids, Herbal Extract, Phytoconstituents
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9693.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9693