ABSTRACT

Bioavailability is an important quality attribute of pharmaceutical dosage forms. Bioavailability is generally improved by gastro-retentive drug delivery systems. Mucoadhesive dosage forms occupy prominent part of these novel drug delivery systems. Glipizide mucoadhesive microspheres were prepared by orifice-ionic gelation technique employing sodium carboxymethyl cellulose and oats powder as mucoadhesive polymers. A total of seven formulae were designed and all the prepared microspheres were subjected to flowability, particle size, percent yield, encapsulation efficiency, in-vitro wash off test, and in- vitro dissolution study. Encapsulation efficiency was present in the range of 85.4% to 89.8%. Microspheres containing oats powder exhibited better mucoadhesive property compared to those containing sod CMC. However in microspheres containing oats powder the drug release was completed within 8-10 hours without sustaining the drug release up to 12 hours. The optimised formulation F7 containing combination of sod CMC and oats powder showed the best results for mucoadhesion and sustained release up to 12 hours. Oats powder was found to be a promising mucoadhesive polymer in the present work. The drug release from all the prepared microspheres followed first order kinetics and diffusion mechanism. Keywords: Sustained release, Glipizide, Mucoadhesive microspheres, ionic gelation technique, in-vitro wash-off test
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9679.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9679