ABSTRACT

An innovative extended-release Ibuprofen formulation offers efficient once-daily treatment for osteoarthritis and rheumatoid arthritis. The current work describes the use of natural polymers such xanthan gum, gelatin, and pectin in the manufacture of an Ibuprofen matrix tablet. Physical characteristics of the tablets, including their drug concentration, hardness, weight fluctuation, and friability, were closely investigated and were determined to be within acceptable bounds. A comparative study showed that the swelling indices of the tablets containing distinctive natural polymers varied, and the tablets containing gelatin had distinct features. Ibuprofen was released in a controlled and prolonged manner, as seen by the release profile, this was particularly apparent in the gelatin matrix. Conclusion: This study opens the door for applications in pharmaceutical formulations by emphasizing the potential of natural polymers when fabricating tablets with sustained-release Ibuprofen and offering insights into their unique release kinetics. Keywords: Ibuprofen, Pectin, Gelatin gum, Xanthan gum, sustained release
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9670.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.12.9670