ABSTRACT

Angiogenesis is defined as the process of formation of new blood vessels. Inhibition of angiogenesis helps in the treatment of cancer, opthalmic condition, rheumatoid arthritis, and other diseases. In this study the anti-angiogenic potential of sesamol, a lignan from sesame seeds, was screened by in-ovo chorioallantoic membrane assay using chicken egg. The images were captured during 0hrs, 24hrs and 48hrs after treatment and was quantified using an AI tool IKOSA. The vascular parameters like vessel total area, vessel total length, vessel mean thickness and vessel number branching points was obtained from the image analysis. The findings of our study revealed that sunitinib did not decrease the vessel area and length in the region of interest. However sunitinib exhibited a significant decrease in the number of branching points when compared with control. The effect of sesamol in altering area, length and thickness was not significant whereas it significantly (p<0.05) decreased the number of branching points when compared with control group. In our study we conclude that sesamol has potential to inhibit angiogenesis but not similar to sunitinib. The conclusions need further support from similar studies which are conducted with longer observation period. Keywords: Anti-Angiogenesis, Sesamol, In-Ovo CAM Assay, IKOSA, Sunitinib
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9669.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9669