ABSTRACT

The present work proposes the development of a distinctive methodology and its subsequent testing to quantify the quantity of escitalopram in both formulations and bulk samples. This analytical method is characterized by its sensitivity, precision, and speed. The analytical procedure was conducted using a UV spectrophotometer and a multivariate calibration process. This multivariate calibration method was created based on the correlation relationship between concentration and absorbance has been determined for five distinct wavelengths, including the highest absorption point at 238nm. The strategy was validated according to the ICH Q2 (R1) requirements, employing linear regression equations along with several mathematical and statistical techniques. All the validation parameters specified in the instructions, including accuracy, linearity, and others, have been successfully met. When utilized for routine examination of medications and compositions, this technique demonstrates sensitivity, cost- effectiveness, and produces dependable outcomes. The technique's The greenness values were assessed using the analytical Eco scale, Agree metrics, and Green Analytical Procedure Index. Keywords: Escitalopram, Multiple variable calibration method, Ultraviolet spectrophotometric, Pharmaceutical Preparation, International Council for Harmonisation regulation, Evaluation
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9655.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9655