ABSTRACT

The alkaloid rich fraction isolated from the aerial parts of Turnera subulata Sm. has been evaluated for acute toxicity and pharmacological screening for anti-anxiety anti-depressant and antistress activities. Acute toxicity study was performed according to the OECD guidelines no:423 and the pharmacological evaluations were also carried out in Swiss albino mice. Anti-anxiety activity evaluated using Elevated plus maze method, Y-maze and antidepressant activity evaluated using Forced swim test and Tail suspension test and anti-stress activity evaluated using cold Swim test and Anoxic stress tolerance test. Phytochemical tests and thin layer chromatography were also performed for the confirmation of alkaloids in the fraction. The alkaloid rich fraction did not show any sign of toxicity up to dose of 2000mg/kg body weight. The alkaloid rich fraction showed an appreciable antidepressant, anti-stress activity and is devoid of anti-anxiety activity. The significant results of both anti-depressant and anti-stress activity were attributed to the phytoconstituents, ‘alkaloid’ which is present in the fraction isolated from the aerial parts of the plant Turnera subulata Sm. Keywords: Acute oral toxicity, Turnera subulata Sm, Anti-Anxiety activity, Anti-stress activity, Anti-depressant activity
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9652.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9652