ABSTRACT

Numerous plants and herbs are used to treat gastrointestinal disorders in traditional medicine. Peptic ulcer is the major gastrointestinal disorder in clinical practice which occurs due to an imbalance between the offensive (gastric acid secretion) and defensive (gastric mucosal integrity) factors consequently, reduction of gastric acid production as well as re-enforcement of gastric mucosal production has been the major approaches for therapy of peptic ulcer disease. Phytotherapy is used as an ancient method of using medicinal plants to treat a wide range of disorders. Recently, the usage of herbal medicines (which are derived from various plant sources) and interest in alternative remedies has increased. Enhydra fluctuans is one of the valuable plants having different pharmacological activities like anti-diabetics, antimicrobial, and anti-inflammatory. Traditionally this plant is used to treat different physiological problems, ulcer is one of them. To support the traditional use of this plant the antiulcer activity of the hydro-alcoholic extract of fresh leaves of Enhydra fluctuans was evaluated by different models (aspirin and stress-induced ulcer model by pyloric ligation method). The 250 mg/kg dose showed prominent antiulcer activity as compared to the control and marketed omeprazole formulation (reduce ulcer formation in aspirin-induced and stress-induced models by Enhydra fluctuans were: 58% and 54.15% respectively). The study demonstrated and confirmed the folkloric claim of the benefit of Enhydra fluctuans in the treatment of ulcers. Keywords: Enhydra fluctuans, Hydroalcoholic extract, Antiulcer activity, Pyloric ligation method
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9651.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9651