ABSTRACT

sublingual administration is chosen over oral tablet administration when a quicker beginning of action is needed. Sublingual pills offer quick drug release from the formulation, avoiding hepatic drug metabolism and going straight into the bloodstream. Throughout the past ten years, there has been a rise in demand for quickly dissolving sublingual pills, particularly from geriatric and pediatric patients who have trouble swallowing. The physicochemical and biological characteristics linked to drug delivery systems' efficacy are being better understood by pharmaceutical scientists, leading to an increase in their complexity. The formulation of sublingual tablets can be done in several ways. such as freeze-drying, direct compression, etc. Sublingual pills must dissolve more quickly. Thus, it is appropriate to prescribe explosives. It is a super disintegrant, meaning that it has a high disintegration efficiency and is effective at low concentrations. Wetness, friability, hardness, weight change, water absorption, disintegration time, and dissolution studies were all assessed for the tablets. Keywords: Sublingual tablets, Drug delivery, sublingual administration, Bioavailability
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9642.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9642