Objectives- Aim of present investigation is to formulate possible lipid-based formulation of drug such
as SMEDDS, SMEDDS is a isotropic mixture of oil, surfactant, and co-surfactant SMEDDS is
thermodynamically stable system and required low energy method, SMEDDS can from oil in water
type micro emulsion type has the potential to deliver poorly water-soluble drugs. selexipag used for
treatment of pulmonary arterial hypertension (PAH) Due to poor water solubility of selexipag, however,
makes it difficult to administer drugs effectively. The use of Micro emulsion systems has shown
promise in improving the bioavailability and solubility of medications that are not very soluble in water.
Methods- To obtain the best possible solubilization of selexipag, the high-speed homogenizer was used
to create micro emulsions using combination of oil phase (coconut oil, Capmul MCM C8, soyabean oil,
corn oil, sunflower oil) and surfactant (tween-80, span-20, tween-20, span-80, Transcutol-HP) and co-
surfactant (propylene glycol, ethanol, PEG-400, propanol, glycerol, Acconon MC8). The formulations
were evaluated in terms of zeta potential, viscosity, particle size and in-vitro release. The stability of
the Micro emulsions was evaluated in a range of storage conditions, including changes in pH.
Results- D-optimal mixture design was selected for the optimization. of 11 experiments for three factors
(amount of Capmul MCM C8, tween-20, Transcutol HP). Zeta potential measurements of optimized
batch confirmed the moderate stability of the Micro emulsion systems.
Conclusion- Micro emulsion becomes a great formulation for poorly water-soluble drugs by increasing
their bioavailability and less side effects A particle size of 226.3 nm suggests that the micro emulsion
has fine particles, which can contribute to stability, optical clarity and enhanced bioavailability if used
for drug delivery. The SMEDDS formulation was found to be novel, effective, safe, stable and patient
friendly. It also overcomes the drawbacks associated with drugs solubility.
Keywords: Selexipag, Micro emulsion, Poorly Water-Soluble Drugs, Pulmonary Arterial
Hypertension, Drug Delivery
Publication date: 01/12/2025
https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9639.pdf
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https://doi.org/10.31032/IJBPAS/2025/14.12.9639
