ABSTRACT

The current study proposes the development and testing of a novel methodology to determine the amount of lobeglitazone in formulations and bulk materials. This analytical method is characterized by its sensitivity, precision, and rapid execution. Utilizing a UV spectrophotometer in conjunction with a multivariate calibration approach, the methodology leverages the established the connection among concentration and absorbance at five. distinct wavelengths, including the absorption maxima at 250 nm. The procedure was validated in accordance with ICH Q2 (R1) guidelines, employing equations for linear regression along with other mathematical and statistical techniques. Validation parameters such as accuracy, linearity, and others specified in the guidelines were successfully met. This technology proves to be sensitive, cost-effective, and reliable for the routine examination of medications and formulations. The technique's greenness was assessed making use of the Green Analytical Procedure Index, AGREE metrics, and Analytical Eco-Scale. Keywords: Lobeglitazone, ICH guidelines, pharmaceutical formulations, UV spectrophotometric analysis, multivariate calibration procedure, and validation
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9609.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9609