ABSTRACT

The current study suggests developing and testing a novel methodology to determine the bulk and formulation concentrations of Cefixime (CEFI). This analytical method can be described as sensitive, precise, and rapid. The investigation was carried up employing a multivariate calibration technique and a UV spectrophotometer. This multivariate calibration approach depends on the proven connection among drug concentration and absorbance that are at 289 nm . Along with other mathematical and statistician instruments, the linear regression equations are used to determine the process to the ICH Q2 (R1) guidelines. Validation parameters linearity, accuracy, and other aspects were all met. This technique, which is used in the routine analysis of therapeutics and formulations, is dependable, cost- effective, and responsive. Keywords: Cefixime, Multivariate calibration technique, UV spectrophotometric, ICH Guidelines
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9601.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.9601