ABSTRACT

According to the current study, a novel methodology should be created and validated in order to ascertain the bulk and formulation amounts of cefpodoxime. This analytical method can be explained as sensitive, exact, and fast. Utilizing a multivariate calibration methodology and a UV spectrophotometer, the analytical approach was executed. A connection between concentration and absorption has been assessed at five different wavelengths, notably the absorbance maximum at 235 nm. This multivariate calibration methodology was established using the aforementioned method. In addition to other mathematical and statistical techniques method was validated by employing linear regression equations under the ICH Q2 (R1) standard. The instructions' validation parameters for linearity, precision, and other factors have all been met. This technology is dependable, sensitive, and economical when used for routine drug and formulation examinations. Keywords: Cefpodoxime, Multivariate calibration method, UV spectrophotometric, Pharmaceutical compositions, ICH standards, Validation
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_9592.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.12.9592