ABSTRACT

In order to accurately determine the concentration of Azilsartan medoxomil in formulations and bulk, the current study advises developing a novel approach and evaluating it. This analytical process can be summarized as sensitive, precise, and rapid. With the aid of a UV spectrophotometer and a multivariate calibration technique, the analytical approach was carried out. The relationship between concentration and absorbance, established at five different wavelengths, including the highest peak absorbance at 250 nm, was used to establish this multivariate calibration technique with methanol as blank. Using the linear regression equations and other mathematical and statistical techniques, the strategy was verified using the ICH Q2 (R1) criterion. Accuracy, linearity, and other validation criteria listed in the instructions have all been attained. When used for periodic evaluations of drugs and formulations, this technology is sensitive, cost-effective, and yields reliable results. Keywords: Azilsartan medoxomil, Multivariate calibration technique, UV spectrophotometric, Pharmaceutical formulations, ICH guidelines, Validation
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_8350.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.8350