ABSTRACT

The objective of the current study is to establish a multilinear regression procedure wholly precise, straightforward, sensitive, and legitimate for the assessment of Olanzapine in commercial tablet dose forms. The multivariate calibration approach was put into effect through generating equations through linear regression analysis, exploiting the correlated relationship amongst absorbance as well as concentration at five unique wavelengths each of which were meticulously selected. The maximum wavelength of olanzapine turned out to be the value of 226 nm. The outcomes were analysed through statistical analysis. A trend towards linearity emerged throughout the concentration range of 7-13 ?g mL-1, with acceptable regression coefficient. The relative standard deviation scores for intra-day and inter-day precision have been established to be 0.42 and 0.39, as well. The assay was performed and resulted in an assortment between 99.20 % to 99.80 % w/w. Keywords: Olanzapine, Antipsychotic, UV spectrophotometry, Multivariate calibration, Assay, ICH guidelines
Publication date: 01/12/2025

https://ijbpas.com/pdf/2025/December/MS_IJBPAS_2025_8344.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.12.8344