ABSTRACT

The purpose of this study is to screen the wound healing properties of a hydro-alcoholic extract of Paederia foetida leaves. Paederia foetida is widely used to treat varieties of skin diseases in the Ayurvedic medicine system, as well as it is also used as folk medicine in wound management. Besides, this been proved scientifically for its anti-microbial, anti-oxidant, and anti-inflammatory activity. So, it can be assumed that Paederia foetida may show potent wound healing activity as the three most important related activities - anti-microbial, anti-oxidant, and anti-inflammatory activity- has already been proved. But still there is no scientific data available on wound healing activity. So, we have attempted to investigate this activity. The hydroalcoholic Paederia foetida leaves extract was obtained by percolation method. Two doses of Paederia foetida (2.5% and 5%) in suitable gel formulation was prepared with the help of HPMC as a gel base to apply topically. Evaluation of the wound healing activity was done by “Excision and Incision wound” models. In the excision wound model, rats treated with Paederia foetida leaves extract showed a significant improvement of the epithelialization time and 50%wound contraction. As well as, the breaking strength of rats treated with Paederia foetida leaves extract increased significantly in an incision wound model as compared to the control group. Paederia foetida leaves extract gel formulations showed likely similar activities as compared to synthetic standard/marketed povidone-iodine as well as herbal standard Aloe vera gel formulation. It can be settled that Paederia foetida leaves extract (2.5 % and 5% gel preparation) has potent wound healing activity. Keywords: Paederia foetida, Phytochemicals, epithelialization time, Breaking Strength, Wound healing, Excision wound model, Incision wound model
Publication date: 01/11/2025

https://ijbpas.com/pdf/2025/November/MS_IJBPAS_2025_9559.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.11.9559