ABSTRACT

This research aims to establish a UV-visible spectroscopic technique for Azelnidipine by applying a multivariate regression equation that is the precise, sensible, and reproducible method. The proposed technique depends on the equation of the linear regression performed by taking absorbance at five distinct wavelengths. Azelnidipine maximum absorbance was obtained at 254 nm using distilled water as the solvent. The graph obtained from concentration 5-15 ?g mL-1 resulted in a linear curve and the regression coefficient was obtained as 0.999 % RSD values for intra-day, as well as inter-day precision, were obtained as 0.5453 and 0.4680. The assay value determined was between 98.40-101.67% w/w. Keywords: Azelnidipine, UV-visible spectroscopy, Assay, ICH guidelines, Multivariate calibration
Publication date: 01/11/2025

https://ijbpas.com/pdf/2025/November/MS_IJBPAS_2025_9555.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.11.9555