ABSTRACT

The objective of the present study was to formulate and optimize floating microspheres of tinidazole. Tinidazole is a BCS class II drug i.e. low solubility and high permeability. The improve solubility of drug using inclusion complex by kneading method with help of ?-CD polymer 1.1 ratio. To achieve these objective nine formulations of microspheres were prepared by congealable disperse phase encapsulation method. A 3² factorial design was employed in formulating the microspheres with Ethyl cellulose and Eudragit S-100 as independent variables. Drug entrapment and Percentages drug release was considered as dependent variable. The proposed floating system was evaluated by preliminary evaluation parameters, micrometric investigation as well as percentage yield of microsphere, Drug entrapment efficiency, Drug content, Floating behaviour, In vitro drug release studies and their kinetics. IR and DSC study confirmed the drug polymer compatibility and scanning electron microscopy indicates that the microspheres were spherical in shape and rough surface. Amongst M4 was found to be the best formulation as it releases Tinidazole 90.26±0.65 in a sustained manner. Formulated microspheres prolonged the drug release by up to 12 hrs. Keywords: Tinidazole, Microspheres, Floating System, Drug entrapment
Publication date: 01/11/2025

https://ijbpas.com/pdf/2025/November/MS_IJBPAS_2025_9496.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2025/14.11.9496