ABSTRACT

Drug repurposing is a technique or approach that identifies expanded uses for pre-approved pharmaceuticals or current therapies. Repurposing has the potential to discover new drugs by leveraging phenotypic advantages, without explicitly explaining the underlying mechanism. The disease-centric approach, the target-centric approach, and the drug-centric approach are the three methods of medication repositioning. Virtual screening is one of the semantic methods for conducting drug repurposing with of computational methods. A molecular docking approach and calculation of binding free energy are used to estimate binding affinity and drug-receptor interactions. Repurposing drugs helps to identify the most promising drugs for further clinical investigation. Drug repurposing suits well for the quickly nascent and reemerging infectious diseases for which no current therapeutics is available. Pharmaceutical companies are undertaking drug repurposing projects for rare diseases, oncology, infectious and autoimmune diseases and more whose drug's safety, pharmacodynamics, and pharmacokinetic qualities were previously established. Over the past 5 years, pressure on the industry caused by the ‘innovation gap’ of rising development costs and stagnant product output have become major reasons for the growing interest in drug repurposing. Two variables could sustain the flow of compounds into repurposing initiatives in the current economic environment. First, there is an increasing desire to add new projects to existing productpipelines, particularly for projects where part of the risk has been eliminated. Secondly, the number of possible compounds that have been shelved for geopolitical concerns is rising. These factors may continue to provide opportunities for academia as well as a small number of successful indications discovery companies. our goal is to conduct a thorough study on drug repositioning by gathering all the relevant information on drug repurposing in a user- friendly manner and providing a concise understanding of it the information we provide id sourced from reputable platforms such as PubMed, Science Direct, Medline and Scopus. Keywords: Drug repurposing, target-centric approach, disease-centric approach, pharmacodynamics
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9528.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9528