ABSTRACT

Immediate Dissolving Formulations (IDFs) have emerged as a promising drug delivery system that addresses patient convenience and compliance issues associated with conventional dosage forms. This review aims to provide an in-depth analysis of IDFs, highlighting their formulation strategies, challenges, and recent developments. IDFs represent a novel approach to drug delivery, offering rapid and convenient administration of pharmaceutical compounds. This abstract provides an overview of the key characteristics and applications of IDFs. IDFs are innovative dosage forms designed to dissolve or disintegrate quickly upon contact with saliva or other aqueous media, releasing the active drug for absorption in the oral cavity. This rapid dissolution eliminates the need for swallowing, making IDFs particularly advantageous for patients with swallowing difficulties, pediatric populations, and individuals requiring fast onsetof action. Various techniques such as freeze-drying, direct compression, and spray- drying have been employed to create IDFs in various forms. IDFs offer several benefits, including enhanced bioavailability due to reduced first-pass metabolism, improved patient compliance, and a more predictable pharmacokinetic profile. Furthermore, they can be tailored to release the drug immediately. Keywords: Immediate Dissolving Formulations (IDFs), drug delivery, pharmacokinetic profile
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9524.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9524