ABSTRACT

Zimad-e-Muhasa is a Unani Pharmacopoeial formulation topically used for Acne treatment. In a randomized controlled clinical study conducted at Jamia Hamdard, New Delhi during 2017-2018, Zimad-e-Muhasa has shown a significantly higher efficacy than benzyl peroxide 5% gel. However, the application of Zimad-e-Muhasa was cumbersome due to its coarse texture and preparation complexity resulting in poor compliance. To improve its topical application and patients’ compliance, Zimad-e- Muhasa was converted and formulated into a topical gel form by dissolving Carbopol 934, combining it with hydroalcoholic extracts of all the ingredients of Zimad-e-Muhasa, and adjusting the pH with Triethanolamine. The physicochemical properties and stability of the herbal gel were assessed, and consistent pH, odour, spreadability, viscosity, microbial growth, and heavy metal content over six months were observed. Optimal consistency and stability were achieved with 2.5% Carbopol 934, maintaining form and spreadability without liquefying or becoming too thick. The gel's near-neutral pH ensured skin compatibility, and stability tests confirmed its robustness. A 2.5% concentration of Carbopol 934 produced a stable, uniform, and adequately spreadable gel with a pH close to neutral, ensuring skin compatibility and minimal irritation. Keywords: Zimad-e-Muhasa; Anti-acne Pharmacopoeial drug; Unani topical drug, Azadirachta indica; Abrus precatorius; Albizia lebbeck
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9518.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9518