ABSTRACT

The biological activities of natural products are well-known and contribute to their value. The present situation has seen a substantial expenditure of resources for studying plant leaf extract and synthesizing nanoparticles with their biological activity. Due to its claimed function as an antitubercular agent in the medical area and its lethality, copper is the metal of choice for synthesizing nanoparticles. In this study, we have used Aegle marmelos (L.) leaf extract to test the antitubercular properties of copper nanoparticles which have been compared with copper nanoparticles made with rutin (flavonoid common in Rutaceae family). The use of DLS verified the synthesis of CuNPs. Further analysis was carried out using UV-Vis spectrophotometer, FTIR and SEM analysis. The findings (ZOI and MIC investigations) showed that copper nanoparticles (made with Aegle marmelos leaf extract) exhibited more potent antitubercular properties in comparison to the copper nanoparticles biosynthesized with rutin when tested against Mycobacterium tuberculosis. Based on the results of these investigations, copper nanoparticles show great efficacy as antitubercular agent. In light of these findings, it is reasonable to assume that medical devices and antitubercular systems are two areas where copper nanoparticles can prove to be an invaluable asset as a therapeutic agent. Keywords: A. marmelos (L.), rutin, biosynthesized copper nanoparticles, antitubercular activity, M. tuberculosis
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9503.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9503