ABSTRACT

Developing orally films is an innovative way to create dose forms that dissolve orally. They have a thin appearance and may be shaped into many different sizes and shapes, such circles or rectangles. The strips may be translucent or opaque, brittle or flexible. Oral films are made of a variety of hydrophilic and hydrophobic polymers that dissolve rapidly on the tongue without the need for water with the objective to enhance the drug's dispersion in the oral cavity, the current effort attempts to develop fast-dissolving oral thin films containing zolpidem tartrate. Zolpidem tartrate films were made by Solvent casting method by using various Polymers such as hydroxy propyl methyl cellulose-E15, starch 1500, and Xanthan Gum polymers. Nine Formulations were Prepared and evaluated. The thickness of the films in all formulations were found to be in the range of 0.7 ± 0.057 mm to 1.1 ± 0.100 mm., physical properties, and surface texture of the prepared films, as well as their folding endurance were found to be 112 – 208, moisture absorption, homogeneity of weight and drug content, swelling index, and in vitro disintegration was found to be 26 to 60sec and the F4 formulation attained 100% drug release with 15 minutes were all taken into consideration when evaluating them. Additionally, stability studies were conducted. Even if each formulation satisfied the evaluation requirements, it is determined that oral thin films with a polymer of 40 mg starch1500 had a superior dissolving profile. Key words: Zolpidem Tartrate, Oral thin Film, Insomnia, Solvent Casting, Oral Cavity
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9495.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9495