ABSTRACT

The objective of this research is to develop a multivariate calibration technique-based UV spectrophotometric method in first derivative method for Imeglimin hydrochloride in bulk and in its pharmaceutical form. The multivariate calibration technique associates the relationship between concentration and amplitude at 5 different wavelengths, hence utilizing the linear regression equations. As a result of this, the instrumental variations are minimized and the correlation is enhanced. When distilled water used as the solvent, Imeglimin hydrochloride indicated a maximum amplitude at 232 nm and linearity between 5 and 15 ?g/mL. The developed approach was found to be simple, linear, accurate, and precise, and it was approved in compliance with ICH requirements. Keywords: Imeglimin Hydrochloride, First order derivative, Multivariate calibration method, Pharmaceutical form, ICH guidelines, Validation
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9478.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9478