ABSTRACT

In this study, we present the synthesis and comprehensive evaluation of novel substituted benzaldehydes derivatives of pyrrolo[2,3-d]pyrimidinehydrazide using an ultrasonic-assisted method. The physicochemical properties of these derivatives were systematically characterized, including melting point determination, solubility analysis, and elemental composition. Spectral studies encompassing UV-Vis, FT-IR, NMR, and mass spectrometry were employed to elucidate the structural attributes and confirm the successful synthesis of the targeted compounds. The use of ultrasound in the synthetic procedure not only enhanced reaction rates but also improved yield and purity, showcasing the advantages of this green chemistry approach. The antimicrobial activity of the synthesized derivatives was evaluated against a panel of Gram-positive and Gram-negative bacteria, as well as fungal strains. The results indicated that the derivatives exhibited significant antimicrobial properties, with certain compounds demonstrating superior efficacy compared to standard antibiotics. Overall, this study highlights the potential of bromo, difluoro, and cyano benzaldehydes derivatives of pyrrolo[2,3-d]pyrimidinehydrazide as promising antimicrobial agents. The combination of ultrasonic synthesis and comprehensive physico-chemical and spectral analysis provides a robust platform for the development of new therapeutic compounds. Keywords: Bromobenzaldehydes, pyrrolo[2,3-d] pyrimidinehydrazide, difluoro benzaldehydes, cyanobenzaldehyde
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9476.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9476