Imidazole has become an important synthon in the development of new drugs. The unique structural
feature of the imidazole (1, 3-diazole) ring with a desirable electron-rich characteristic is beneficial for
imidazole derivatives to readily bind with various enzymes and receptors in biological systems through
diverse weak interactions, thereby exhibiting broad bioactivities. The derivatives of 1, 3-diazole show
different biological activities such as antibacterial, antimycobacterial, anti-inflammatory, antitumor,
antidiabetic, anti-allergic, antipyretic, antiviral, antioxidant, anti-amoebic, antihelmintic, antifungal,
and ulcerogenic activities, etc. The present study, 2,4,5-triphenyl imidazole derivatives were
synthesized using benzil, substituted aldehydes, ammonium acetate, and triethylammonium acetate.
The synthesized compounds were characterized using mass spectroscopy and evaluated for antibacterial
activity. The antibacterial report shows that compounds 1a and 1b show a maximum zone of inhibition
against Bacillus subtilis.
Keywords: 2,4,5-triphenyl imidazole derivatives, bioactivity score, antibacterial activity
Publication date: 01/10/2025
https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9475.pdf
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https://doi.org/10.31032/IJBPAS/2025/14.10.9475
