ABSTRACT

Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis that can affect any synovial- lined diarthrodial joint, but it prefers the wrist and minor joints of the hand. The normal natural history of RA is one of increasing articular deterioration leading to joint deformities and impairment. Indeed, the understanding that tumour necrosis factor alpha plays a key role in joint inflammation and destruction has resulted in the introduction of TNF-? targeting medications, which have had a significant influence on the care of RA patients. The recognition that autoimmunity to citrullinated proteins is extremely specific for RA and may be harmful is an essential insight into the disease. According to the results of the current investigation, an ethanolic extract of Raphanus sativus Linn leaf may have therapeutic benefits for treating rats' arthritis. The outcomes of the present study show the benefits of Raphanus sativus Linn leaf in the treatment of arthritis and the reduction of clinical symptoms, such as paw volume, arthritic index, radiographic and histological investigation. The findings of the study demonstrate that the plant extract significantly reduces inflammation, protects joints, and has anti-arthritic properties. Keywords: Rheumatoid arthritis, paw volume, arthritic index, auto-immune, anti-arthritic activity
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9468.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9468