ABSTRACT

The objective of this work was to synthesize xanthine derivatives and evaluate the anti-obesity action. The compounds were yellow to brown in color and obtained in 68-71 % yields and were slightly soluble in water, insoluble in methanol and DMSO while they were soluble in chloroform. The confirmation of the structures of the compounds was done by 1H-NMR, mass and IR spectral study. Compounds 4a-e were found to be hypophagic and restrict the intake of food by the mice and the hyperphagic effect of (±) - 8- OH-DPAT was antagonized by them. Keywords: Xanthine, obesity, hyperlipidemia, food intake, cardiovascular
Publication date: 01/10/2025

https://ijbpas.com/pdf/2025/October/MS_IJBPAS_2025_9282.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.10.9282