ABSTRACT

The objective of this work was to study the effect of essential oil of Cypress tree on central nervous system by using various neurobehavioural tests. The neurobehavioral effect of the essential oil (CEO) was studied by monitoring its effect on anxiety, locomotion and nociception. In the elevated plus maze apparatus, the number of entries in the open arm of EPM was 6.0 ± 1.2247 at 200 mg/kg CEO and 6.4 ± 0.8944 at 400 mg/kg dose. In the locomotion test using actophotometer, mice treated with CEO were also able to reduce the number of crossings (score) to 294.4 ± 2.4083 at 200 mg/kg dose and 253.6 ± 3.4351 at 400 mg/kg dose. The precent reduction in locomotion was found to be 16.22 and 28.11 % respectively at the low and high dose of CEO suggesting a significant reduction in comparison to the basal score. In order to measure the anti-nociceptive action mediated through the CNS, eddy plate was used. The latency to response was a measure analgesia induced by the drug. Mice treated with CEO were able to enhance the latency period significantly at both the doses. The latency period after 90 min was 5.50 ± 0.0733 sec and 6.48 ± 0.0961 sec for 200 mg/kg and 400 mg/kg respectively while that after 120 min was 5.65 ± 0.0327 and 6.92 ± 0.0686 respectively. This suggest a dose dependent anti-nociceptive action of CEO. The results led to the conclusion that Cypress tree essential oil possess the ability to influence to working of the central nervous system. Keywords: Cypress, neurobehavior, locomotion, analgesia, anxiety
Publication date: 01/09/2025

https://ijbpas.com/pdf/2025/September/MS_IJBPAS_2025_9360.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.9.9360