ABSTRACT

The review explores the versatile nature of phenothiazine, a highly adaptable heterocycle with significant implications in medicinal chemistry. It delves into various synthetic methods for preparing phenothiazine derivatives, emphasizing the tricyclic structure's role as a fundamental framework. Substitution of the NH group can significantly impact pharmacological activity, influencing interactions with biological targets. The review covers areas such as anticancer activity, highlighting the potential of phenothiazine derivatives against a spectrum of cancer cell lines. Additionally, it discusses antioxidant activity, crucial for neutralizing free radicals, and antifungal activity against various yeast and mold strains. These insights underscore the potential applications of phenothiazine derivatives in drug discovery and development, promising avenues for combating cancer, oxidative stress, and fungal infections. This comprehensive overview provides a foundation for further research and synthesis in the pursuit of novel pharmaceutical agents. Keywords: Phenothiazine, Synthetic procedure-microwave and conventional method, Cancer, Microbial, Alzeimer’s, Tubercular
Publication date: 01/09/2025

https://ijbpas.com/pdf/2025/September/MS_IJBPAS_2025_9278.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.9.9278