Pastilles are medications that dissolve in the mouth, formed of solidified liquid. The pastillation technique
is a novel method that transforms bulk chemical liquid into solid, bead-like granules, making them ideal for
bagging, shipping, and bulk material handling systems. Pastillation has been used to improve solubility of
drugs, using high molecular weight, non-melting synthetic amorphous polymers that improve the solubility
and dissolution rates of poorly water-soluble medicines. In situ coating is a process of applying a protective
layer to a substrate, improving the functionality, stability, and performance of final particles. Pulsatile
release dosage forms maximize drug distribution for better therapeutic results, allowing for regulated
distribution, improved bioavailability, and customized drug release patterns. Controlled release systems,
such as capsules, patches, or implants, play a crucial role in pharmaceuticals, agriculture, and other
industries. Controlled release multiparticulate systems consist of several small drug depots, offering
patients therapeutic benefits and greater product development flexibility. This study provides a new option
for creating immediate and modified release drug delivery systems, replacing traditional tablets and
capsules.
Keywords: Pastilles, Pastillation, Solubility enhancement, In situ coating, Pulsatile release,
Controlled release
Publication date: 01/09/2025
https://ijbpas.com/pdf/2025/September/MS_IJBPAS_2025_9210.pdf
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https://doi.org/10.31032/IJBPAS/2025/14.9.9210
