ABSTRACT

The importance of Phyto pharmaceuticals in medicine has long been noted, thus it is imperative to look into safe and effective medications for the treatment of metabolic diseases. Diabetes is a metabolic disease associated with changes in the structure and function of several biological systems. The main cause of tissue injury is persistent hyperglycaemia. While peripheral neuropathy and small- and large-vascular disease may also be used to explain diabetes-related organ failure, throughout the past 20 years, the harmful consequences of persistent hyperglycemia have extended beyond angiopathy and neuropathy. A fungus fruit extract of the Liophyllum dicastes, a leaf extract of the Butea monosperma, and fruit extract of the Opuntia dillenil was shown by phytochemical testing. The study findings of Butea Monosperma distilled (300 mg/kg) and Liophyllum decastes, Opuntia dillenelli on DM rats lured with STZ were correlated with Glibenclamide. diabetes that was created by experimentation and eventually led to diabetic neuropathic problems. Blood glucose levels, body weight, grip strength, writing, mechanical hyperalgesia, spontaneous locomotor (exploratory) test, lipid profile analysis, and thermal hyperalgesia were among the parameters that demonstrated thedrug's protective effects against diabetes and diabetic neuropathy. It was discovered that the liver and sciatic nerve cells of the treated groups showed less inflammation, deterioration, and necrosis. Shown were the antidiabetic properties and diabetic neuropathy of the distilled leaves of Butea Monosperma, fruit extract of the Opuntia dillenil and a fungus found in Liophyllum decastes. Keywords: Diabetic neuropathy, Liophyllum decastes, Butea Monosperma
Publication date: 01/08/2025

https://ijbpas.com/pdf/2025/August/MS_IJBPAS_2025_9369.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.8.9369