ABSTRACT

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely utilized for their potent analgesic and anti- inflammatory properties, but concerns have been raised regarding their potential cardiovascular risks. This comprehensive review critically examines the existing literature on the cardiovascular safety profiles of commonly prescribed NSAIDs. The discussion encompasses the known cardiovascular risks associated with NSAID use, including an elevated risk of myocardial infarction, stroke, and heart failure, elucidating the underlying mechanisms involving cyclooxygenase (COX) enzyme inhibition and altered prostaglandin synthesis. A thorough analysis of key clinical studies, randomized controlled trials, and observational data provides insights into the varying degrees of cardiovascular risk associated with different NSAIDs. The review emphasizes the importance of patient-specific risk stratification and management strategies, advocating for vigilant monitoring and adherence to regulatory guidelines to minimize potential cardiovascular complications. By synthesizing the current evidence and highlighting the complexities involved in balancing the therapeutic benefits and cardiovascular hazards of NSAIDs, this review aims to facilitate informed decision-making for clinicians and healthcare professionals,underscoring the need for continued research and surveillance to ensure the safe use of NSAIDs in clinical practice. Keywords: NSAIDs; Cardiovascular Risk; COX; Safety Profile; Myocardial Infraction
Publication date: 01/08/2025

https://ijbpas.com/pdf/2025/August/MS_IJBPAS_2025_9346.pdf

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https://doi.org/10.31032/IJBPAS/2025/14.8.9346